In Reply Our Viewpoint1 summarized animal studies with respect to the association of cyclooxygenase (COX) 2 and prostaglandin-E2 (PGE2) disruption with neurodevelopment, including the use of COX inhibitors such as aspirin or indomethacin.1 Relevant research needs to be introduced in pediatric clinical discussions and warrants future neurobehavioral studies, especially because clinical data will probably lead to (1) treatment of considerably more pregnant women (almost 11% of total) at high risk for preeclampsia with low-dose aspirin (LDA) and (2) increased and prolonged fetal exposure to aspirin.2
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Voutetakis A, Pervanidou P, Kanaka-Gantenbein C. Vital Considerations for Aspirin in Prevention of Preeclampsia, a Multifaceted Pregnancy Disorder—Reply. JAMA Pediatr. 2020;174(1):95–96. doi:10.1001/jamapediatrics.2019.4021
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