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Research Letter
December 20, 2019

Association Between Use of Multiple Classes of Antibiotic in Infancy and Allergic Disease in Childhood

Author Affiliations
  • 1F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland
  • 2Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland
  • 3Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland
JAMA Pediatr. 2020;174(2):199-200. doi:10.1001/jamapediatrics.2019.4794

Antibiotic administration negatively affects the microbiome by decreasing bacterial diversity, and this has been associated with allergic disease.1-3 Exposure to multiple classes of antibiotics may lead to even greater perturbations to the gut biome than 1 class alone. The purpose of this study is to determine whether exposure to multiple antibiotic classes in infancy is associated with a higher risk of developing allergic disease in early childhood.

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