To the Editor It is interesting to note that Green et al1 observed a differential association between child sex and maternal urinary fluoride (MUF) and poorer cognitive outcomes in boys, which indicates that boys are more vulnerable to the developmental toxicity of fluoride than girls. However, the authors did not explore the biological plausible mechanistic reasons that would explain the different biological responses to prenatal exposure, which would contribute to the adverse sex specific neurodevelopmental outcomes observed in this study.
Waugh D. Association Between Maternal Fluoride Exposure and Child IQ. JAMA Pediatr. 2020;174(2):211–212. doi:10.1001/jamapediatrics.2019.5233
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