[Skip to Navigation]
Comment & Response
January 27, 2020

Vitamin D Supplement During Pregnancy and Enamel Defects in Offspring—Reply

Author Affiliations
  • 1Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Ledreborg Allé 34, DK-2820 Gentofte, Denmark
JAMA Pediatr. 2020;174(3):304-305. doi:10.1001/jamapediatrics.2019.5731

In Reply We found in a double-blind, randomized, placebo-controlled trial that high-dose vitamin D supplementation during pregnancy was associated with reduced risk of recurrent wheeze1 and enamel defects in offspring.2 Deng and Niu suggest that this finding was flawed by residual confounding. However, the design mitigates confounding. This is demonstrated in our study showing equal distribution of lifestyle-related factors between groups. Therefore, our results cannot be biased from residual confounding.

Add or change institution
Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words