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Comment & Response
January 27, 2020

Vitamin D Supplement During Pregnancy and Enamel Defects in Offspring—Reply

Author Affiliations
  • 1Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Ledreborg Allé 34, DK-2820 Gentofte, Denmark
JAMA Pediatr. 2020;174(3):304-305. doi:10.1001/jamapediatrics.2019.5731

In Reply We found in a double-blind, randomized, placebo-controlled trial that high-dose vitamin D supplementation during pregnancy was associated with reduced risk of recurrent wheeze1 and enamel defects in offspring.2 Deng and Niu suggest that this finding was flawed by residual confounding. However, the design mitigates confounding. This is demonstrated in our study showing equal distribution of lifestyle-related factors between groups. Therefore, our results cannot be biased from residual confounding.

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