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Comment & Response
March 16, 2020

Limited Clinical Application and Concerns of Bias in Long-term Risk of Epilepsy, Psychiatric Disorders, and Mortality Following Febrile Seizures

Author Affiliations
  • 1Paediatric Department, Nepean Hospital, Penrith, New South Wales, Australia
  • 2Sydney Medical School Nepean, The University of Sydney, Penrith, New South Wales, Australia
JAMA Pediatr. Published online March 16, 2020. doi:10.1001/jamapediatrics.2020.0043

To the Editor We read with interest the article by Dreier et al,1 which demonstrated that febrile seizure is associated with risk of epilepsy, but more importantly, also psychiatric disorders. The risk of psychiatric disorders was found to be 17.2% at birth, 21.4% after the first, 25% after the second, and 29.1% after the third febrile seizure. The study included any psychiatric disorders in the ranges of International Classification of Diseases, Eighth Revision, 290-315 and International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, F00-F99 as registered in the Psychiatric Central Register. To be able to apply this information into the clinical setting, it would be most useful to know which of the diagnoses were most frequently made following previous febrile seizures. Therefore, could the authors please investigate which of the International Statistical Classification of Diseases and Related Health Problems diagnoses were most prevalent after the first, second, and third febrile seizures and at which ages these diagnoses were most commonly made.

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Article Information

Corresponding Author: Helen Puusepp-Benazzouz, MD, PhD, DCH, Sydney Medical School Nepean, Nepean Hospital, The University of Sydney, PO Box 63, Penrith, NSW 2751, Australia (helen.puuseppbenazzouz@health.nsw.gov.au).

Published Online: March 16, 2020. doi:10.1001/jamapediatrics.2020.0043

Conflict of Interest Disclosures: None reported.

Dreier  JW, Li  J, Sun  Y, Christensen  J.  Evaluation of long-term risk of epilepsy, psychiatric disorders, and mortality among children with recurrent febrile seizures: a national cohort study in Denmark.  JAMA Pediatr. 2019;173(12):1164-1170. doi:10.1001/jamapediatrics.2019.3343PubMedGoogle ScholarCrossref