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Comment & Response
March 16, 2020

Limited Clinical Application and Concerns of Bias in Long-term Risk of Epilepsy, Psychiatric Disorders, and Mortality Following Febrile Seizures—Reply

Author Affiliations
  • 1National Centre for Register-Based Research, Department of Economics and Business Economics, Aarhus University, Aarhus, Denmark
  • 2Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark
  • 3Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
JAMA Pediatr. Published online March 16, 2020. doi:10.1001/jamapediatrics.2020.0046

In Reply We thank Puusepp-Benazzouz and Bhurawala and Granild-Jensen et al for their interest in our work1 on long-term risk of epilepsy, psychiatric disorders, and mortality in children with recurrent febrile seizures. In this study, we reported a 30-year cumulative risk of any psychiatric disorder of 17.2% (95% CI, 17.2-17.3) in the overall population, 21.4% (95% CI, 21.0%-21.9%) following a first febrile seizure, 25.0% (95% CI, 24.0%-26.1%) following a second febrile seizure, and 29.1% (95% CI, 27.2%-31.0%) following a third febrile seizure.

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