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Comment & Response
April 13, 2020

Including Second Impact Syndrome in Sports-Related Concussions Evidence Review—Reply

Author Affiliations
  • 1The Harborview Injury Prevention and Research Center, Departments of Pediatrics and Epidemiology, University of Washington, Seattle
  • 2Center for Child Health, Behavior and Development, Seattle Children’s Research Institute, Seattle, Washington
  • 3David Geffen School of Medicine, Departments of Pediatrics and Neurosurgery, University of California, Los Angeles Steve Tisch Brain SPORT program, University of California, Los Angeles Mattel Children’s Hospital, Los Angeles
  • 4Departments of Pediatrics and Psychiatry and Behavioral Sciences, George Washington University School of Medicine, Washington, DC
  • 5Children’s National Health System, Rockville, Maryland
JAMA Pediatr. Published online April 13, 2020. doi:10.1001/jamapediatrics.2020.0540

In Reply Casper raises the question of why we excluded discussion of second impact syndrome in our consensus statement.1 Second impact syndrome is an important topic with differing opinions regarding its pathophysiology and risk factors.2 More research is needed to accurately estimate the risk of second impact syndrome and to learn best prevention strategies. For these reasons, our panel elected not to include second impact syndrome as one of the questions to address. In addition, current understanding is that this syndrome appears to occur when a person who is already symptomatic from a current brain injury sustains a second impact to the brain. Laws in all 50 states and the District of Columbia currently specifically say that symptomatic players are not to return to play until provided medical clearance.

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