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Research Letter
June 8, 2020

Association of Prenatal Opioid Exposure With Precentral Gyrus Volume in Children

Author Affiliations
  • 1Department of Psychiatry and Behavioral Science, Oklahoma State University Center for Health Sciences, Tulsa
  • 2National Center for Wellness and Recovery, Oklahoma State University Center for Health Sciences, Tulsa
  • 3Department of Human Development and Family Science, Oklahoma State University, Tulsa
  • 4Laureate Institute for Brain Research, Tulsa, Oklahoma
JAMA Pediatr. Published online June 8, 2020. doi:10.1001/jamapediatrics.2020.0937

Prenatal opioid exposure is associated with delayed locomotor performance at multiple stages of early child development1,2 and with smaller neuroanatomical structures, such as the basal ganglia.3 The motor cortex, which controls speech and motor skills, may also be vulnerable to drug exposure, but to our knowledge, this has yet to be assessed. Identifying risks of exposure associated with brain structures is critical for prevention and intervention strategies for cognitive effects that can last long after conception.3,4

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