In Reply We thank Abbasi and Puusepp-Benazzouz for raising an important question about our study that was published in JAMA Pediatrics, “Association of Maternal Psychological Distress With In Utero Brain Development in Fetuses With Congenital Heart Disease.”1 In healthy fetuses, we reported that maternal trait anxiety was negatively associated with left and right hippocampal volumes. However, these associations were no longer significant after adjusting for multiple testing.1 Following Abbasi and Puusepp-Benazzouz’s suggestion, we further investigated whether brain volumes were different in healthy fetuses with high (positive) maternal psychological distress vs low (negative) maternal psychological distress. We found that healthy fetuses of pregnant women with high trait anxiety had significantly smaller left (mean, 0.508 cm3 vs 0.540 cm3; P = .007) and right (mean, 0.539 cm3 vs 0.578 cm3; P = .01) hippocampal volumes compared with healthy fetuses of pregnant women with low trait anxiety. There were no differences in other brain regions (ie, total brain, cerebrum, cerebellum, and brainstem) between healthy fetuses in pregnancies with high vs low maternal psychological distress.
Wu Y, Limperopoulos C. Pregnancy Stress, Anxiety, and Depression Sequela on Neonatal Brain Development—Reply. JAMA Pediatr. 2020;174(9):908–909. doi:10.1001/jamapediatrics.2020.1079
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