More than 40 000 children undergo cancer treatment in the United States annually,1 and all patients experience symptoms and adverse effects from their therapy or their disease. Clinical use of patient-reported outcomes (PROs), which are standardized reports of a patient’s health condition directly from the patient, has the potential to alleviate some of this experience, allow patients and their caregivers to feel more in control of their well-being, help their health care team better control symptoms, and improve outcomes. In adults, using PRO tools to monitor symptoms and toxic effects during chemotherapy improves patients’ quality of life, decreases their number of hospitalizations, and lengthens their life.2,3