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Research Letter
November 23, 2020

Polysubstance Involvement in Opioid Overdose Deaths in Adolescents and Young Adults, 1999-2018

Author Affiliations
  • 1Department of Pediatrics, Boston Medical Center, Boston, Massachusetts
  • 2Department of Health Law, Policy, and Management, Boston University School of Public Health, Boston, Massachusetts
  • 3Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island
JAMA Pediatr. 2021;175(2):194-196. doi:10.1001/jamapediatrics.2020.5035

From 1999 to 2016, opioid-related mortality among adolescents and young adults aged 13 to 25 years (referred to as youth) increased 3-fold.1 Opioid overdose deaths in adult populations often involve other substances, particularly benzodiazepines and, increasingly, stimulants.2,3 Little is known about polysubstance involvement in opioid overdose deaths among youth. In this cross-sectional study, we examined national trends in polysubstance-involved opioid overdose deaths among youth in the US.

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