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Comment & Response
January 19, 2021

Pros and Cons in Using Population-Based Registers for Assessing the Fetal Safety of Drugs

Author Affiliations
  • 1Department of Obstetrics and Gynecology, Ente Ospedaliere Cantonale, Università della Svizzera Italiana, Lugano, Switzerland
  • 2Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, and Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland
JAMA Pediatr. 2021;175(4):427. doi:10.1001/jamapediatrics.2020.5314

To the Editor Andersson et al1 investigate the risk of adverse fetal outcomes associated with the use of a second-generation antihistamine (fexofenadine) among 2962 pregnancies with fexofenadine use matched in a 1:1 ratio with those with the use of the currently recommended second-generation antihistamines (cetirizine). No association has been noted between fexofenadine use during pregnancy and increased risk of major birth defects, spontaneous, preterm birth, and stillbirth.

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