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Research Letter
January 25, 2021

Diabetic Ketoacidosis at the Time of Diagnosis of Type 1 Diabetes in Children: Insights From TRIGR

Author Affiliations
  • 1Department of Pediatrics, Montreal Children’s Hospital, McGill University, Montreal, Quebec, Canada
  • 2Division of Bioinformatics and Biostatistics Pediatric Epidemiology Center, Department of Pediatrics, University of South Florida, Tampa
  • 3Division of Endocrinology, UPMC Children’s Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania
  • 4Department of Pediatrics, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada
  • 5Linköping University Hospital, Linköping, Sweden
  • 6Division of Pediatrics, Department of Clinical and Experimental Medicine, Medical Faculty, Linköping University, Linköping, Sweden
  • 7University of Helsinki, Helsinki, Finland
  • 8Helsinki University Hospital, Helsinki, Finland
JAMA Pediatr. Published online January 25, 2021. doi:10.1001/jamapediatrics.2020.5512

Type 1 diabetes (T1D) is one of the most common chronic diseases of childhood. If left untreated, diabetic ketoacidosis (DKA), a largely preventable life-threatening complication, will occur. Currently, 19% of Canadian children and 40% of US children will present with DKA at the time of diagnosis of T1D.1,2 Because symptoms of T1D exist before the onset of DKA, 1 risk factor for DKA is a delay in the diagnosis and treatment of T1D. Other risk factors include younger age (<5 years) and lower socioeconomic status (SES).1

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