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Comment & Response
January 25, 2021

Efficacy of 3 Major Ketogenic Diet Therapies in Children With Drug-Resistant Epilepsy

Author Affiliations
  • 1Epilepsy Research Center of PLA, Department of Neurosurgery, Xinqiao Hospital, Army Medical University, Chongqing, China
JAMA Pediatr. 2021;175(4):434. doi:10.1001/jamapediatrics.2020.5448

To the Editor We read with interest the Original Investigation “Efficacy of Ketogenic Diet, Modified Atkins Diet, and Low Glycemic Index Therapy Diet Among Children With Drug-Resistant Epilepsy: A Randomized Clinical Trial” by Sondhi et al,1 published in JAMA Pediatrics. The authors indicate that the modified Atkins diet and low glycemic index therapy diet are not noninferior to the classic ketogenic diet (KD) with respect to seizure reduction at 24 weeks after diet initiation among children with drug-resistant epilepsy. There are several concerns about this study.

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