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Comment & Response
April 5, 2021

Consideration of Sex Differences in Children With Obesity—Reply

Author Affiliations
  • 1Department of Prevention, Rehabilitation and Sports Medicine, School of Medicine, University Hospital Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
JAMA Pediatr. 2021;175(7):748-749. doi:10.1001/jamapediatrics.2021.0253

In Reply In the Letter to the Editor regarding our article “Obesity Genes and Weight Loss During Lifestyle Intervention in Children With Obesity,”1 Li and Tang suggested dividing our study population by sex to consider heterogeneity between boys and girls. This is well perceived, and we agree that there are important differences between sexes in the associations between obesity-related single-nucleotide variants (SNVs) and body weight, which has been shown by several studies in adults, revealing stronger effects in women.2,3 This seems to be apparent already in childhood,4 although the overall evidence in children is scarce.

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