Cerebral palsy (CP) is a group of major neurodevelopmental disabilities that mainly affect early motor development, with movement, posture, and secondarily musculoskeletal impairments.1 The motor disorders are often associated with other neurodevelopmental diseases, such as intellectual disability, speech or language impairment, autism spectrum disorder, attention deficit, or comorbidities, such as epilepsy or psychiatric disorders, relative to the general population.2 Currently, early diagnosis of high-risk CP offers the opportunity for early intervention at a critical developmental plasticity window. The earlier we intervene, the better the outcome is. The international clinical guideline by Morgan et al3 in this issue of JAMA Pediatrics advocates, based on a high standard of evidence, for an early intervention for children aged 0 to 2 years who have CP or are at high risk of CP. This is a time window that encompasses maximum brain plasticity.