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Comment & Response
May 24, 2021

Inadequate Dosage of Mycophenolate Mofetil Is Likely to Yield Substandard Trial Results and Substandard Patient Care—Reply

Author Affiliations
  • 1Division of Nephrology, Dialysis and Transplantation, Istituto Giannina Gaslini IRCCS, Genoa, Italy
  • 2Department of Medicine, University of Calgary, Calgary, Alberta, Canada
  • 3Laboratory on Molecular Nephrology, Istituto Giannina Gaslini IRCCS, Genoa, Italy
JAMA Pediatr. 2021;175(8):870-871. doi:10.1001/jamapediatrics.2021.1068

In Reply We thank the authors of the 2 letters responding to our randomized clinical trial (RCT) comparing mycophenolate mofetil (MMF) and rituximab in the treatment of steroid-dependent nephrotic syndrome (SDNS).1 They provide us the opportunity to further discuss the main finding of our study, specifically the minimum effective dose of MMF in the treatment of complicated nephrotic syndrome. Schreuder et al and Belluzzi et al raised an important point, contesting that previous studies had already established the appropriate dosage of MMF for SDNS.

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