High childhood low-density lipoprotein cholesterol (LDL-C) levels often track into adulthood and contribute to atherosclerosis later in life. Therefore, it is important to understand LDL-C levels during childhood to inform primordial prevention of high LDL-C levels and downstream atherosclerosis. However, age-related longitudinal LDL-C trajectories during childhood have not been well characterized.1 Additionally, childhood prevalence of very high LDL-C levels consistent with the phenotype of familial hypercholesterolemia (FH) in the US is largely unknown.2
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Zhang Y, Woo JG, Urbina EM, Jacobs DR, Moran AE, de Ferranti SD. Low-Density Lipoprotein Cholesterol Trajectories and Prevalence of High Low-Density Lipoprotein Cholesterol Consistent With Heterozygous Familial Hypercholesterolemia in US Children. JAMA Pediatr. Published online July 19, 2021. doi:10.1001/jamapediatrics.2021.2046
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