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Research Letter
July 19, 2021

Low-Density Lipoprotein Cholesterol Trajectories and Prevalence of High Low-Density Lipoprotein Cholesterol Consistent With Heterozygous Familial Hypercholesterolemia in US Children

Author Affiliations
  • 1Division of General Medicine, Columbia University Irving Medical Center, New York, New York
  • 2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio
  • 3Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis
  • 4Department of Pediatrics, Harvard Medical School, Boston, Massachusetts
JAMA Pediatr. Published online July 19, 2021. doi:10.1001/jamapediatrics.2021.2046

High childhood low-density lipoprotein cholesterol (LDL-C) levels often track into adulthood and contribute to atherosclerosis later in life. Therefore, it is important to understand LDL-C levels during childhood to inform primordial prevention of high LDL-C levels and downstream atherosclerosis. However, age-related longitudinal LDL-C trajectories during childhood have not been well characterized.1 Additionally, childhood prevalence of very high LDL-C levels consistent with the phenotype of familial hypercholesterolemia (FH) in the US is largely unknown.2

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