In this issue of JAMA Pediatrics, Pereira et al1 report on a sizable group of healthy newborns screened with whole-exome sequencing (WES) shortly after birth whose world—and the world of their parents—did not end in psychological and emotional Armageddon (so far). Does this mean that we are ready to offer WES to each of the 4 million infants born annually in the US? No. Does it mean that we have made a critical first step in understanding the potential benefits and harms of screening newborns with WES? Absolutely.