[Skip to Navigation]
Views 484
Citations 0
Viewpoint
September 7, 2021

Early-Onset Kidney Stone Disease—Consequences and Opportunities

Author Affiliations
  • 1Division of Pediatric Urology, Department of Surgery, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
  • 2Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia
  • 3Division of Pediatric Nephrology, Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
  • 4Department of Urology, Medical College of Wisconsin, Milwaukee
JAMA Pediatr. Published online September 7, 2021. doi:10.1001/jamapediatrics.2021.2966

Kidney stone disease (nephrolithiasis), a disorder of mineral metabolism, results in recurring symptomatic events that account for billions of dollars in annual health care costs. Historically, nephrolithiasis affected older adult men but now is increasingly occurring earlier in life. Early-onset kidney stone disease has also increased among all Black youths, predominantly among Black females.1 The prevalence of nephrolithiasis in the United States increased from 5% (in 1988 to 1994) to 9% (in 2007 to 2010)2; among all age groups, the greatest increase in the annual incidence of nephrolithiasis is among adolescents. This earlier age at onset has increased the number of children presenting to the emergency department, admitted to the hospital, and requiring surgery, effects compounded by a 50% recurrence rate of symptomatic stone events within 5 years of diagnosis.3 The rapid emergence of nephrolithiasis as a disease of childhood has revealed deficiencies in our understanding of the epidemiology of the disease and exposed critical gaps in the evidence informing treatment decisions. This Viewpoint explores these deficiencies and proposes a framework to address these gaps in order to improve outcomes for this vulnerable population.

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words
    ×