Benzodiazepines are commonly prescribed to pediatric patients despite a narrow range of approved indications.1 Like opioids, benzodiazepines are subject to prescription drug misuse and have been associated with increased risk of opioid overdose and opioid-related mortality in adolescents and young adults.2-4 Because limited information is available on the use of benzodiazepines in these age groups, we examined trends in benzodiazepine prescriptions dispensed during a 12-year period, including potential treatment indications and concurrent use with opioids.