The authors of the recent report of the effectiveness of duct tape in the treatment of warts in children postulated that local irritation from the duct tape may have stimulated an immune response that led to wart resolution.1 The observation that, in some cases, distant, untreated warts also resolved with the duct tape intervention suggests a systemic immune response. There is precedent for local therapy (intralesional injection of warts with mumps or Candida antigen) to produce resolution not just of the treated wart but also of distant, untreated warts, presumably through a systemic immune response.2
Allen JJB, Dveirin K. Mechanism of Wart Disappearance: An Alternative Hypothesis. Arch Pediatr Adolesc Med. 2003;157(5):490. doi:10.1001/archpedi.157.5.490-a
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