This issue provides a veritable international smorgasbord of high-quality investigations into the prevalence, burdens, risk and protective factors, and outcomes of children and adolescents with psychosocial difficulties. The bad news is that these problems are pervasive, persistent, and interrelated. The good news is that we have some clues about how to better detect, prevent, and treat some of these conditions. Let's look a little closer at what these articles are trying to teach us.