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October 2005

Reevaluating Antibiotic Therapy for Urinary Tract Infections in Children

Arch Pediatr Adolesc Med. 2005;159(10):992-993. doi:10.1001/archpedi.159.10.992

Urinary tract infection (UTI) is a common pediatric problem, with 2% of all children experiencing one by the age of 10 years. In addition, between 2.5% and 10% of children with fever without localizing signs have a UTI.1 Thus, the pediatrician is faced with treatment decisions frequently. For many years, therapy was straightforward, but the situation has changed. Both the lay and medical literature report that bacteria are becoming increasingly resistant to commonly used antibiotics. Gram-negative enteric organisms, the most common cause of UTI, are particularly problematic. With widespread use of expanded spectrum antibiotics, a number of highly effective resistance mechanisms have evolved.2 Clinicians are often uncertain how to treat.

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