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January 1951


AMA Am J Dis Child. 1951;81(1):2-14. doi:10.1001/archpedi.1951.02040030009002

SYMMETRICAL cortical necrosis of the kidneys has been regarded as uncommon at any age. Until recently only about 100 cases have been published.1 The occurrence of symmetrical cortical necrosis of the kidneys in infants was unknown until 1949, when Campbell and Henderson2 described two instances, one in a 5 month old infant, the other in a 9 week old infant.

Originally the disturbance was thought to be a specific complication of pregnancy, but it is now clear that it can occur in either sex at any age. According to the comprehensive review by Duff and Murray,1 the etiology of symmetrical cortical necrosis is varied. Of the cases in which pregnancy was not a factor, the majority seem to have been associated with acute infection, such as diphtheria, scarlet fever, pneumonia or malaria. Poisoning with a variety of substances, shock following trauma, extreme dehydration and purpura have also