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March 1951

FAMILIAL LEUKEMIA: A Report of Leukemia in Five Siblings, with a Brief Review of the Genetic Aspects of This Disease

Author Affiliations

From the Dight Institute for Human Genetics and the Department of Pediatrics, University of Minnesota.

AMA Am J Dis Child. 1951;81(3):313-322. doi:10.1001/archpedi.1951.02040030323001

THE OCCURRENCE of multiple cases of leukemia within a single family has often been sufficiently striking to merit a published report by the clinician who encountered it. An excellent review of such cases has been made by Videbaek,1 who has summarized 26 "incontrovertible" cases in the literature up to 1947 and has added 13 cases of his own.

The family to be described in the present report is unique in several respects. It is the first reported with leukemia in more than three siblings, and it represents an easily studied group, for all affected members have been examined and treated in the University of Minnesota Hospitals within the last 14 years.

CLINICAL MATERIAL  The pedigree of the "S." family is shown in the figure. Only the near relatives are included, and the affected persons are indicated by solid symbols. There have been no consanguineous marriages. This pedigree has not been

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