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Article
April 1951

IMMUNIZATION IN THE YOUNG INFANTResponse to Combined Vaccines: VI-X

AMA Am J Dis Child. 1951;81(4):518-529. doi:10.1001/archpedi.1951.02040030529005
Abstract

VI. TETANUS  IN THE preceding sections of these reports we have discussed methods, reactions and the specific antibody responses to pertussis and diphtheria antigens. In this section we shall consider the problems relevant to tetanus immunization.In tetanus immunization of the young infant, and of older children and adults as well, one is dealing with a situation much less complex than those encountered in diphtheria and pertussis prophylaxis. There is for practical purposes no problem of preimmunization passive immunity to modify the response. Only one person in our group showed tetanus antitoxin before immunization. The exception was an older child who had been given passive prophylaxis. Furthermore, the antigen currently used is so devoid of reaction capacity that massive stimuli may be utilized in routine practice without fear of exciting significant reactions. This antigen uniformly evokes high levels of antitoxin and a high anamnestic capacity.The effectiveness of tetanus immunization

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