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Article
May 1951

TREATMENT OF TYPHOID IN CHILDREN WITH CHLORAMPHENICOL (CHLOROMYCETIN®): Report of Seven Cases

Author Affiliations

CHICAGO
From the Sarah Morris Hospital for Children and the Department of Bacteriology and Virology, Medical Research Institute, Michael Reese Hospital, Chicago.

AMA Am J Dis Child. 1951;81(5):636-650. doi:10.1001/archpedi.1951.02040030649003
Abstract

IN THE year 1948 Woodward1 obtained excellent results in the treatment of 10 patients with endemic typhoid on the Malay Peninsula with chloramphenicol (chloromycetin®). Two patients relapsed, but a second course of therapy was effective. By 1949 this series had been extended to 44 cases, with continued excellent results.2 Further reports on the treatment of endemic typhoid with chloramphenicol in India have been made by Shah.3 Vakil4 and Patel.5 In the 53 cases reported by them, there were 7 relapses which responded to a second course of therapy and 3 deaths5 occurring in the first 48 hours of treatment. Shah3 felt that results were excellent only in those cases in which treatment was started before the tenth day of illness. Knight6 treated 13 patients in Mexico, with good results. Murgatroyd7 reported one case from Great Britain in which treatment for only

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