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June 1951

L'Organisation des os.

AMA Am J Dis Child. 1951;81(6):871-872. doi:10.1001/archpedi.1951.02040030885027

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This monograph, which is a compendium of the author's work of the past several years, sets forth his present interpretation of bone growth and the "organizers" which, he believes, control the process. The work is presented as the results of a series of experiments (mostly with rabbits), but, unfortunately, detailed data are nowhere outlined. This circumstance makes it very difficult to evaluate various statements and even to differentiate between fact and theory. A great deal of space is given to an attempt to prove the presence of organizers in extracts of skeletal tissue, and most of the rest of the book is built on the idea that such substances are, in fact, demonstrable. In view of the recent work of Heinen and his associates, who were able to duplicate Lacroix's results with nonspecific irritants, the existence of "osteogenin" cannot be considered as proved. The difficulties of evaluation are increased by

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