THE PURPOSE of this investigation was to evaluate the results obtained in the management of premature infants who received vitamin A and D supplements in aqueous dispersions, as compared with the results obtained in premature infants who received vitamin A and D supplements in oily solution. Special attention was paid to rickets and retrolental fibroplasia.
Diminished intestinal absorption of fat-soluble vitamin A in the premature and newborn infant has been established.1 This may explain why Shelling and Hopper2 found that higher doses of synthetic oleovitamin D (viosterol) are needed for the prevention of rickets in the premature infant than in the older child. In 1946 a paper from this laboratory reported that vitamin A is more readily absorbed from an aqueous than from an oily medium.3 This observation has since been amply confirmed.4 It is of special significance in the management of the premature, since
KRAMER B, GORDON SM, BERGER HM, SOBEL AE. AQUEOUS DISPERSIONS OF VITAMINS A AND D IN PREMATURE INFANTS: Studies with Reference to Rickets and Retrolental Fibroplasia. AMA Am J Dis Child. 1951;82(1):17–27. doi:10.1001/archpedi.1951.02040040024004
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