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July 1951

AQUEOUS DISPERSIONS OF VITAMINS A AND D IN PREMATURE INFANTS: Studies with Reference to Rickets and Retrolental Fibroplasia

Author Affiliations

From the Departments of Pediatrics and Biochemistry, The Jewish Hospital of Brooklyn.

AMA Am J Dis Child. 1951;82(1):17-27. doi:10.1001/archpedi.1951.02040040024004

THE PURPOSE of this investigation was to evaluate the results obtained in the management of premature infants who received vitamin A and D supplements in aqueous dispersions, as compared with the results obtained in premature infants who received vitamin A and D supplements in oily solution. Special attention was paid to rickets and retrolental fibroplasia.

Diminished intestinal absorption of fat-soluble vitamin A in the premature and newborn infant has been established.1 This may explain why Shelling and Hopper2 found that higher doses of synthetic oleovitamin D (viosterol) are needed for the prevention of rickets in the premature infant than in the older child. In 1946 a paper from this laboratory reported that vitamin A is more readily absorbed from an aqueous than from an oily medium.3 This observation has since been amply confirmed.4 It is of special significance in the management of the premature, since

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