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March 1952

EGG ALLERGY IN CHILDREN: Incidence and Evaluation in Relation to Chick-Embryo-Propagated Vaccines

Author Affiliations

From the Departments of Pediatrics and Immunology, New York Medical College, Flower and Fifth Avenue Hospitals, and the Pediatric Division of Sea View Hospital.

AMA Am J Dis Child. 1952;83(3):309-316. doi:10.1001/archpedi.1952.02040070055006

EGG IN relation to the problem of food allergy is perhaps too well understood today to warrant more than passing comment. It assumes new interest, however, in its bearing on the increasing use of viral and rickettsial vaccines prepared from chick embryos. Clinical experience with such vaccines indicates that their use may be fraught with danger in those cases in which the patients are sensitive to egg. A study of the incidence and interpretation of egg sensitivity that may be encountered in a random population, as well as in allergic persons, is therefore pertinent.

INCIDENCE OF EGG SENSITIVITY IN NONALLERGIC CHILDREN  Normal persons have been tested with egg proteins to evaluate the significance of skin tests, and the general survey suggests an incidence of egg sensitivity of less than 1% in a random group of infants and children. Blackfan1 found no positive reactors among 43 children tested with egg

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