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Article
April 1952

ACUTE RETICULOENDOTHELIOSIS (LETTERER-SIWE DISEASE): Report of a Case in Which Several Unusual Features Are Combined

Author Affiliations

WICHITA, KAN.
From the Wichita Foundation of Medical Research.

AMA Am J Dis Child. 1952;83(4):475-480. doi:10.1001/archpedi.1952.02040080071006
Abstract

SINCE Letterer's description 24 years ago,1 about 30 to 35 cases of acute nonlipid reticuloendotheliosis have reached the literature. Reticuloendothelial disease of this type has not been completely defined because of the small number of cases.2

We have recently encountered a case of fatal reticuloendotheliosis in which were combined a number of the less frequently mentioned features of this disease. It supports the idea of Wallgren3 and others that the whole group represents varying degrees of pathologic change in the reticuloendothelial system.

REPORT OF A CASE  A white, 16-month-old boy entered Wesley Hospital on March 16, 1950, with a chief complaint of pallor, fever, and loss of weight. This child was a full-term infant with normal delivery, weighing 7 lb. 6 oz. (3,350 gm.) at birth. He was breast-fed until 9 months of age and in good health until that time. The mother had no illness during

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