SINCE 1945 when penicillin became available for general use, several investigators have reported on its use in the treatment of scarlet fever. Although there has been general agreement on the satisfactory therapeutic role of penicillin, there is no moderately close agreement as to method of administration, type of agent used, and duration of treatment. It is felt that a satisfactory standardization of treatment might be suggested by a correlation of our results with those of other investigations.
Our objective is twofold: first, to report the results of a critical clinical investigation of the effect of penicillin in the treatment of 386 scarlet fever patients, and second, to review briefly the current opinions of present-day writers in this field.
The study included 386 patients whose duration of illness was four days or less before hospitalization. There were 185 males and 201 females in the group. All were hospitalized immediately
MATHIEU PL, MATHIEU BJ, WEST EJ. SCARLET FEVER: Evaluation of Continuous and Intermittent Penicillin Therapy. AMA Am J Dis Child. 1952;83(5):628–636. doi:10.1001/archpedi.1952.02040090074007
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