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June 1952


AMA Am J Dis Child. 1952;83(6):782-787. doi:10.1001/archpedi.1952.02040100080008

NEUROBLASTOMA is a malignant tumor primarily of infancy and early childhood. Ordinarily this tumor grows rapidly, metastasizes widely and early, and is soon fatal. The average duration of life after diagnosis is less than six months. The tumor grows from cells tracing their origin to the primitive neural crest of the ectoderm and therefore is said to be neurogenic in origin. Commonly the site of the original tumor is the medulla of the adrenal gland which is derivative of the neural crest. Less often the tumor arises in sympathetic tissue elsewhere in the body.

That this tumor is not or need not be invariably fatal is well shown in the most recent review of the literature on this subject by Beck and Howard.1 In their review they found 475 cases reported, with 47, or 10%, recorded as cures. This is probably not an accurate over-all picture, because the disease