THE DEVELOPMENT of reliable semimicroanalytic procedures has permitted more precise studies of the circulating iodine fractions.1 As a consequence, much of the confusion resulting from methodologic inadequacies and from the use of blood instead of serum samples has been eliminated. In brief, applications of these methods have revealed that the level of serum inorganic iodide in healthy adults varies, as might be expected, with the intake of this halide, but with an ordinary diet it only infrequently exceeds 1 γ per 100 ml.2 The major fraction, called protein-bound or serum-precipitable iodine, ranges in euthyroid adults between 4 and 8 γ per 100 ml.,3 remains quite constant in any one person from week to week.4 and from the point of view of solubility, behaves like thyroxine.5 Thyrotoxicosis6 and uncomplicated pregnancy7 are characterized by elevations of both protein-bound iodine and of thyroxine.8 Hypothyroidism, or
DANOWSKI TS, HUFF SJ, ERHARD LH, et al. PROTEIN-BOUND IODINE LEVELS IN NORMAL AND IN DIABETIC CHILDREN. AMA Am J Dis Child. 1952;84(1):5–10. doi:10.1001/archpedi.1952.02050010021002
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