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July 1952

Pharmacological Basis of Penicillin Therapy.

AMA Am J Dis Child. 1952;84(1):137. doi:10.1001/archpedi.1952.02050010153015

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"The purpose of this monograph has been to present briefly the pharmacological basis of penicillin therapy in a concise and reasonably complete form." This is the introductory sentence in the preface, and the word "clearly" could well have been added. The text is preceded by an excellent table of contents which gives the reader, in a very few minutes, a clear idea of the subject, and each of the seven chapters is introduced by a summary of less than a page of fine print.

The first two chapters discuss the absorption, distribution, concentration, and elimination of penicillin into the various fluids, tissues, organs, and cavities of the body when given by various channels, i. e., orally, subcutaneously, intravenously, etc.

Chapter III introduces the clinical phase of the subject, and when one bears in mind the wide variation in the natural course of most human illnesses, one understands the difficulties in

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