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Article
August 1952

PERTUSSIS: Treatment with Aureomycin; Clinical Study of Eighty-Five Patients and Seventy-Four Controls

Author Affiliations

PHILADELPHIA
From the Philadelphia Hospital for Contagious Diseases.

AMA Am J Dis Child. 1952;84(2):184-190. doi:10.1001/archpedi.1952.02050020048005
Abstract

RECENT reports in the medical literature suggest that aureomycin might be effective in the treatment of pertussis. At the present time there is much to be desired in the treatment of pertussis even with the drugs now available. Many reports have been made on the benefits of human and rabbit antipertussis serum, the sulfonamides, pertussis vaccine, ascorbic acid, penicillin, polymyxin B, and streptomycin.1 The search for a more effective therapeutic agent continues. Many of the antibiotics heretofore recommended for the treatment of pertussis are highly effective against Hemophilus pertussis in vitro but not in vivo. Aureomycin has been reported recently2 to be effective in the treatment of pertussis. Most of the reports are based upon observations of small series of patients, and many of the studies lack parallel control.

The purpose of this study is to compare the course of pertussis in patients treated with aureomycin with the

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