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September 1952

WATER INTOXICATION: Report of Case in Which Cumulative-Chloride-Balance Data Aided Diagnosis and Therapy

Author Affiliations

Fellows in Pediatrics (Dr. Baskin) and Fellow in Medicine (Dr. Scribner), Mayo Foundation, University of Minnesota, from the Section of Pediatrics, Mayo Clinic (Dr. Keith).

AMA Am J Dis Child. 1952;84(3):351-354. doi:10.1001/archpedi.1952.02050030077009

AFTER the development of a practical clinical method for measuring chloride balance,1 this technic was applied to pediatric patients in order to evaluate it as a diagnostic aid and therapeutic guide in the parenteral administration of fluid and electrolyte. The results of this preliminary study will be published later. This report is of a case of water intoxication in which the cumulative-chloride-balance study was believed to contribute to the diagnosis and therapy.

REPORT OF CASE  A 7-month-old girl infant who weighed 8,800 gm. and was 72 cm. long was hospitalized because of exstrophy of the urinary bladder. Physical examination revealed a well-developed and well-nourished infant with no additional abnormalities. Preoperative blood chemistry determinations, including a value for blood urea of 38 mg. per 100 cc., were within normal limits. A cumulative-chloride-balance study was started at 11 a. m. on July 18, 1950, when the infant had just been