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November 1952

LIPID NEPHROSIS IN CHILDREN: Observations Over a Period of Twenty-Six Years

Author Affiliations

From the Pediatric Service of the Mount Sinai Hospital, New York.

AMA Am J Dis Child. 1952;84(5):587-600. doi:10.1001/archpedi.1952.02050050061003

IN A PREVIOUS communication1 we reported our observations on children with the nephrotic syndrome over a 20-year period. We wish now to report on observations for over six additional years of some of these patients. We shall also report on additional patients seen subsequently.

MATERIAL  The material consists of the following: (1) patients who died while under observation and (2) patients now alive followed for a period of 4 years to 26 years. All these patients were seen by one of us (J. L. K.) at the Mount Sinai Hospital at frequent intervals during the entire period.All patients on admission gave a history of an insidious onset of illness and generalized recurrent edema. They had a normal or slightly elevated blood pressure, massive albuminuria, normal or moderately increased blood urea content, a high serum lipid level, and a low serum protein concentration.We shall first discuss the patients