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Article
March 1953

PURPURA IN INFANTS AND CHILDREN: Its Natural History

Author Affiliations
NEW HAVEN, CONN.; BOSTONFellow in Hematology, supported in part by the Commonwealth Fund of New York and the Charles P. Hood Foundation of Boston (Dr. Clement).; From the Department of Pediatrics, Harvard Medical School and the Infants' and Children's Hospitals and the Hematology Research Laboratory, Children's Medical Center, Boston.
AMA Am J Dis Child. 1953;85(3):259-278. doi:10.1001/archpedi.1953.02050070269001
Abstract

IN RECENT years, the increasing frequency of the occurrence of purpura in childhood has made more important an understanding of the natural history of the disease and the problem of proper management of these patients. Opinion has varied from the one extreme of doing nothing or as little as possible, in the hope that the child will "outgrow" a tendency to bruise easily or bleed freely after minimal trauma, to the other of urging radical treatment such as early splenectomy because of the danger of uncontrollable and possibly fatal hemorrhage. Each course may be defended on the basis of personal experience with one or a few patients. A pediatrician may be impressed by the number of children who have relatively little trouble with purpura and recover in a few weeks or months and decide no surgical treatment is ever needed. A surgeon who is called upon to operate on a

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