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March 1953

HYPERVITAMINOSIS A A Review with a Discussion of Vitamin AA Review with a Discussion of Vitamin A

AMA Am J Dis Child. 1953;85(3):316-334. doi:10.1001/archpedi.1953.02050070328007

It is of use from time to time to take stock, so to speak, of our knowledge of a particular disease, to see exactly where we stand in regard to it, to inquire to what conclusions the accumulated facts' seem to point, and to ascertain in what directions we may look for fruitful investigations in the future.

William Osler, Gulstonian Lectures, 1885.


A. Introduction  IT HAS long been known among Eskimos and arctic travelers that the ingestion of polar-bear liver may cause illness. One of the earliest descriptions of this disorder was mentioned by the arctic explorer, Elisha Kane,1 in 1857:when I was out in the Advance with Captain De Haven, I satisfied myself that it was a vulgar prejudice to regard the liver of bear as poisonous. I ate of it freely myself and succeeded in making it a favorite dish with the

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