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April 1953

NEPHROTIC SYNDROME IN CHILDREN: Observations on the Clinical Course and the Influence of Sulfonamide and Antibiotic Therapy

Author Affiliations

From the Kunstadter Laboratories for Pediatric Research, the Department of Pediatrics, Sarah Morris Hospital for Children, and Mandel Clinic of Michael Reese Hospital, Chicago. The Research Department is supported in part by the Chicago League for Nephritic Children and by the Michael Reese Research Foundation.

AMA Am J Dis Child. 1953;85(4):451-461. doi:10.1001/archpedi.1953.02050070465004

THIS STUDY was planned to analyze recent clinical experience and to determine the influence of sulfonamide and antibiotic therapy on the course of children with the nephrotic syndrome. The case histories of children with this condition who were admitted to the hospital from 1944 to 1950 were reviewed, and the course after discharge of each was studied. This time interval was chosen since it was during this period that intensive use was made of sulfonamides and antibiotics for this condition. No attempt will be made to review the literature, as this has been done thoroughly in recent articles.1

MATERIALS AND METHODS  The records of all children with the nephrotic syndrome admitted from 1944 to 1950, inclusive, were examined, and all the patients in this group still living in 1951 were reexamined. There were 29 such patients (aged 10 months to 6 years) admitted during this interval with the characteristic

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