THIS STUDY was planned to analyze recent clinical experience and to determine the influence of sulfonamide and antibiotic therapy on the course of children with the nephrotic syndrome. The case histories of children with this condition who were admitted to the hospital from 1944 to 1950 were reviewed, and the course after discharge of each was studied. This time interval was chosen since it was during this period that intensive use was made of sulfonamides and antibiotics for this condition. No attempt will be made to review the literature, as this has been done thoroughly in recent articles.1
MATERIALS AND METHODS
The records of all children with the nephrotic syndrome admitted from 1944 to 1950, inclusive, were examined, and all the patients in this group still living in 1951 were reexamined. There were 29 such patients (aged 10 months to 6 years) admitted during this interval with the characteristic
PHILIPS I, CALVIN JK, KAGAN BM. NEPHROTIC SYNDROME IN CHILDREN: Observations on the Clinical Course and the Influence of Sulfonamide and Antibiotic Therapy. AMA Am J Dis Child. 1953;85(4):451–461. doi:10.1001/archpedi.1953.02050070465004
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