IT IS GENERALLY agreed that hemolytic disease of the newborn is usually caused by antibodies formed in Rhesus-negative mothers against the Rh factor D (Rh0) of Rhesus-positive children. According to Wallerstein1 this mechanism accounts for 92%, according to Mollison2 for some 95%, of all cases of the disease. Of the remaining instances, a few are due to sensitization of the mother against one of the other Rh antigens or against an antigen belonging to a different blood group system such as Kell. This still leaves a residue of unexplained cases, and in many of these incompatibility of the major ABO blood groups has been held responsible.
By now a considerable number of instances of the disease attributed to maternal anti-A or anti-B antibodies has been recorded all over the world. In 1948, Grumbach and Gasser3 fully reviewed the literature of the subject and added nine cases
DUNN HG. HEMOLYTIC DISEASE OF THE NEWBORN DUE TO ABO INCOMPATIBILITY. AMA Am J Dis Child. 1953;85(6):655–674. doi:10.1001/archpedi.1953.02050070672004
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