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July 1953

I. Growth and Metabolism in Normal Infant Rhesus Monkeys (Macaca Mulatta)

Author Affiliations

From the Department of Pediatrics and Pediatric Section, Metabolic Unit of the University of California Medical School, (Dr. Pickering, Dr. Smyth, and Dr. Fisher); from the Department of Obstetrics and Gynecology, Yale University School of Medicine (Dr. van Wagenen).

AMA Am J Dis Child. 1953;86(1):1-10. doi:10.1001/archpedi.1953.02050080008001

LONG-TERM investigations designed to characterize the metabolic and endocrine features of growth and development in the human infant have been limited by a multiplicity of uncontrollable protean factors, included among which are heredity, a relatively slow rate of maturation, and our inability to prescribe the total environment of any child and his respective family. Use of primates other than man, while a recognizable escape from such limitations, has not been previously practicable due to the following considerations: (1) the need of a well-standardized primate colony on which sufficient growth and developmental data had been collected to warrant application of small numbers to such investigations; (2) the unavailability of techniques mandatory to successful management of member animals under experimental conditions; (3) the need for research tools, such as the application of tracer techniques and ultramicrochemical analyses, which were usually not within the practical domain of laboratories conducting such studies.

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