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July 1953

II. Growth and Metabolism in Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta)

Author Affiliations

From the Department of Pediatrics and Pediatric Section of the Metabolic Unit of the University of California Medical School.

AMA Am J Dis Child. 1953;86(1):11-22. doi:10.1001/archpedi.1953.02050080018002

THIS COMMUNICATION presents a study of infant rhesus monkeys rendered athyroid by I131 administration. Its justification rests upon the premise that a better understanding of the effects of thyroidectomy in infant catarrhine primates might broaden our understanding of human cretinism. Aberrations in growth and development and correlated metabolic changes following thyroid ablation are reported. This report is one of a series on the growth and development of normal and thyroid-ablated infant rhesus monkeys.1

Previously reported studies on effects of thyroidectomy in the young rhesus monkeys are limited to those of Fleischmann and co-workers.2 They observed that while no other physical effects were seen, one of the two rhesus animals which they surgically thyroidectomized at 8 months (the other of which died within a few days following surgery) showed no appreciably significant growth during a 21-week survival period.

Earlier reports upon the effects of (surgical) thyroidectomy in adult rhesus