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August 1953

IV. Radiosodium (Na24) Space in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta)

Author Affiliations

From the Department of Pediatrics (Dr. Pickering and Dr. Fisher) and the Radioactivity Research Center (Dr. Scott), University of California Medical School.

AMA Am J Dis Child. 1953;86(2):157-161. doi:10.1001/archpedi.1953.02050080166003

THE PURPOSE of this communication is to relate Na24 "space" data with previously reported growth and metabolic studies in normal and thyroid-ablated infant macaque monkeys.1

Na24 "space" was sought as a measure of one relatively constant increment of total body mass and was determined at varying intervals during growth and compared in normal and myxedematous subjects.

METHODS  Techniques of animal care and feeding have been reported in a previous communication.1a Radiosodium (Na24) was procured from the Oak Ridge National Laboratory, where it was prepared by neutron bombardment of sodium carbonate. The half-life of Na24 is 14.9 hours. Samples received in this laboratory were prepared as isotonic sterile solutions and diluted with 0.85% NaCl to contain approximately 10 μc per cubic centimeter at the time of animal injection. The quantity of isotope present in samples was determined with a scintillation counter. This was composed of