[Skip to Navigation]
Article
August 1953

ENDOCARDIAL FIBROELASTOSIS: Report of Unusual Case with Impaired Ability to Fabricate Serum Proteins

Author Affiliations

MINNEAPOLIS; LOS ANGELES
From the Department of Pediatrics, University of Minnesota, Minneapolis, and the Department of Pediatrics, University of California School of Medicine at Los Angeles.

AMA Am J Dis Child. 1953;86(2):186-197. doi:10.1001/archpedi.1953.02050080195007
Abstract

ENDOCARDIAL fibroelastosis or endocardial sclerosis until recently has been looked upon as a pathologic diagnosis.1 With the growing interest in this condition, attempts have been made to define this as a clinical entity and one which in many cases can be diagnosed ante mortem.2

The postmortem findings of endocardial fibroelastosis have been described in infants from 3 days to 5 years of age; the majority of the deaths have been of infants between 4 and 9 months. Generally speaking, three clinical patterns have been noted, characterized best by their course: (1) sudden death occurring 24 to 48 hours after the onset of symptoms of respiratory distress; (2) prolonged progressive increase in dyspnea, anorexia, irritability, occasional vomiting, cardiac failure, and death; (3) repeated episodes of respiratory distress and cardiac failure which respond well to oxygen and digitalis and which may last months or even years.

The purpose of this

×