THESE introductory sentences which appear in the review by Ingelfinger, Lowell, and Franklin1 reflect the present status of this form of allergy. Evidence to support this diagnosis has been grouped into three categories: experimental studies, clinical observations, and laboratory tests. A brief summary of their conclusions is helpful in the interpretation of the general aspects of intestinal allergic disorders.
Experimental studies should theoretically be designed to fulfil the following requirements: "Symptoms should be caused by contact with a specific substance that is innocuous to the bulk of the population; an immune mechanism should be evident in their pathogenesis; lesions and functional changes in the gut should be demonstrable." In this respect the work of Walzer and his co-workers2 is most informative. They injected serum obtained from a patient highly sensitive to peanuts into the skin of the arm, into the rectal mucosa, and into the intestinal mucosa in
ROTHMAN PE. DIARRHEA OF ALLERGIC ORIGINA Review. AMA Am J Dis Child. 1953;86(2):201–210. doi:10.1001/archpedi.1953.02050080210009
Customize your JAMA Network experience by selecting one or more topics from the list below.