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November 1953

Growth and Metabolism in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta): VI. Iodine Metabolism in Normal and Thyroid-Ablated Infant Rhesus Monkeys (Macaca Mulatta)

Author Affiliations

From the Department of Pediatrics, and from the Radioactivity Research Center (Dr. Scott), University of California School of Medicine, from Yale University School of Medicine (Dr. van Wagenen).

AMA Am J Dis Child. 1953;86(5):574-586. doi:10.1001/archpedi.1953.02050080587003

As one of a series of integrated reports regarding the role of thyroid in growth and metabolism of normal and I131 thyroid-ablated infant rhesus monkeys,1 this communication presents quantitative aspects of iodine metabolism.

Earlier reports of thyroid function in rhesus monkeys are limited to observations on thyroidectomized mature animals,2 except in the study of Fleischmann and

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co-workers,2a where two 8-month-old animals were also observed. Of the reported studies,2 none have dealt with iodine metabolism per se, nor have they been concerned with the role of thyroid in growth and development. In all cases, thyroidectomy was achieved either by prolonged administration of thiouracil3 or by surgical means—the latter frequently being complicated by severe and often fatal hypoparathyroidism.4 When thiouracil was used, large doses (0.8 gm. per day) were found necessary to produce hypothyroidism and thyroid hyperplasia in adult animals,