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January 1954

IDIOPATHIC CALCINOSIS UNIVERSALIS: Report of a Case in a Child Treated with Corticotropin (ACTH) and Cortisone

Author Affiliations

From the Department of Pediatrics, Howard University College of Medicine, and the Pediatric Service of Freedman's Hospital.

AMA Am J Dis Child. 1954;87(1):55-62. doi:10.1001/archpedi.1954.02050090055007

CALCINOSIS is the term applied to the abnormal deposition of calcium salts into the skin, subcutaneous tissues, muscles, and tendons. The disease is usually divided into two clinical types, depending upon whether the deposit is localized (calcinosis circumscripta) or generalized (calcinosis universalis). The latter type is the severer of the two and is the variety usually observed in children and young adults. The condition is uncommon, and only sporadic reports have appeared in the pediatric literature.

The cause and pathogenesis are obscure; however, certain workers1 believe that the condition is related to scleroderma and dermatomyositis. Because of the reported efficacy of corticotropin (ACTH) and cortisone in certain of the collagen diseases and in view of the lack of a specific treatment for calcinosis, we elected to administer these hormones in this case.

REPORT OF CASE  This 11-year-old girl was admitted Aug. 31, 1951, with a chief complaint of "lumps"

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